Caltech Micromachining Laboratory
Electrolysis-Based On-Chip Dispensing System for ESI-MS
Project Abstract
We report here an integrated on-chip sample dispensing system
for Electrospray Ionization-Mass Spectrometry (ESI-MS) applications.
The stand-alone chip includes an electrolysis-based micropump, a
passive micro mixer and an ESI nozzle. Operation of the chip doesn’t
require any external fluidic coupling because the chip is designed
to have samples filled, sealed and stored in reservoirs inside the
chip before testing. Demonstrated here is a chip with two sample
reservoirs and dispensing of the samples is electrically controlled
individually. Experimentally, on-chip co-dispensing of two different
samples is successfully achieved with a dispensing flow rate about 50
nl/min and a continuous spray for 2 minutes.
References
J. Xie, Q. He, Y.C. Tai, J. Liu and T. Lee, "Electrolysis-Based On-Chip Dispensing System for ESI/MS," Proceedings, The
Sixteenth IEEE International Conference on Micro Electro Mechanical Systems (MEMS '03), Kyoto, Japan, Jan. 19-23, pp. 443-446, (2003).
Involved Personnel
Jun Xie, Qing He
, Yu-Chong Tai, Jun Liu and Terry Lee
Related Publications
X.Q. Wang, A. Desai, Y.-C. Tai, L. Licklider, T.D. Lee, “Polymer-Based Electrospray Chips for
Mass Spectrometry”, The 12th IEEE International Conference on Micro Electro Mechanical Systems (MEMS’99),
Orlando, Florida, 1999, pp. 523-528
J. Xie, X. Yang, X.Q. Wang and Y.C. Tai, “Surface Micromachined Leakage Proof
Parylene Check Valve”, The 14th IEEE International Conference on Micro Electro
Mechanical Systems (MEMS’01), Interlaken, Switzerland, 2001, pp.539-542