  Address: 1200 E California Blvd , Caltech MS 136-93, Pasadena, CA, 91125  EDUCATIONPh.D., Electrical Engineering GPA 4.1/4.3 California Institute of Technology , Pasadena , CA (07/2002 – 06/2007) MS, Electrical Engineering GPA 4.0/4.0 Pennsylvania State University, University Park, PA, (08/1998 – 12/2000) Ph.D. Candidate, Biochemistry and Molecular Biology GPA 3.96/4.0 Pennsylvania State University, University Park, PA, (08/1996 – 07/1998) BS, Biological Sciences and Biotechnology GPA 87/100 Tsinghua University, Beijing, P.R.CHINA, (09/1992 – 07/1996) RESEARCH EXPERIENCEPostdoctoral Scholar, Electrical Engineering, California Institute of Technology, CA (07/07 – present) Advisor: Prof. Yu-Chong Tai On-going research:
Graduate Assistant, Electrical Engineering, California Institute of Technology, CA (07/02 – 06/07) Advisor: Prof. Yu-Chong Tai Ph.D. dissertation: "On-chip blood count", California Institute of Technology, Pasadena, CA, May 2007
Graduate Assistant, Electrical Engineering, Pennsylvania State University, PA (05/99 – 12/00) Advisor: Prof. Hao Che M.S. thesis: “A framework for the performance analysis of pricing and bandwidth allocation in a multiple class-of-service Internet”, Pennsylvania State University, University Park, PA, December 2000 Research on: Network services modeling, analysis with Stochastic process and numerical analysis, and simulation study with C++ programming Research Rotation and Graduate Assistant, Biochemistry and Molecular Biology, Pennsylvania State University, PA (08/96 – 06/98) Research includes: molecular biology on gene transcription factors, mammalian cell culture, plant physiology, bacteria physiology, and protein kinetics Research Assistant, Biological Sciences and Biotechnology, Tsinghua University, Beijing, P. R. China (06/95 – 08/96) Advisor: Prof. Haimeng Zhou B.S. thesis: Several aspects on protein structure function relationship Research on protein folding and enzyme kinetics by modeling and experimental approaches TEACHING EXPERIENCEMentor, Electrical Engineering, California Institute of Technology, CA (07/2003 – present) Five junior lab members, one undergraduate thesis, and two summer student Teaching Assistant, Electrical Engineering, Pennsylvania State University, PA (01/2000 – 12/2000) Teach junior level laboratory of electronic circuit design, and junior level laboratory of embedded syste Teaching Assistant, Biochemistry and Molecular Biology, Pennsylvania State University, PA (08/1997 – 05/1998) Teach sophomore level elementary biochemistry laboratory, and senior level molecular genetics laboratory INDUSTRY EXPERIENCEMember of Technical Staff I Lucent Technologies, Inc, Holmdel, NJ (04/2001 – 09/2001) Summer Intern Hughes Network System, Germantown, MD (05/00 – 08/00) PUBLICATIONSRefereed Journal Articles [1] H. K. Lin*, S. Zheng*, R. H. Datar, Y.-C. Tai, and R. J. Cote, "Portable Filter-Based Microdevice for Detection of Circulating Tumor Cells," (submitted), 2007. (*Authors with equal contribution) [2] S. Zheng, J.-Q. Liu, and Y. C. Tai, "Streamline Based Microfluidic Device for Erythrocytes and Leukocytes Separation in Human Blood," IEEE/ASME J. of Microelectromechanical Systems (in revision), 2007. [3] S. Zheng, J. C.-H. Lin, H. L. Kasdan, and Y. C. Tai, "Leukocyte Counting and Differentiation from Undiluted Whole Blood Samples," Sensors and Actuators B Chemical, vol. DOI 10.1016/j.snb.2007.11.031 (in print), 2007. [4] S. Zheng, M. S. Nandra, C. Y. Shih, W. Li, and Y. C. Tai, "Resonance Induced Impedance Sensing of Human Blood Cells," Sensors & Actuators: A. Physical, vol. DOI 10.1016/j.sna.2007.10.047 (in print), 2007. [5] S. Zheng, M. Liu, and Y. C. Tai, "Micro coulter counters with platinum black electroplated electrodes for human blood cell sensing," Biomedical Microdevices, vol. DOI 10.1007/s10544-007-9128-5 (in print), 2007. [6] S. Zheng*, H. Lin*, J.-Q. Liu, M. Balic, R. Datar, R. J. Cote, and Y.-C. Tai, "Membrane microfilter device for selective capture, electrolysis and genomic analysis of human circulating tumor cells," Journal of Chromatography A, vol. 1162, pp. 154-161, 2007. (*Authors with equal contribution) [7] H. Che, S. Zheng, and X. Hong, "Integrated model for performance analysis of multiple class-of-service Internet," IEE proceedings. Communications, vol. 149, p. 139-146, 2002. [8] J. H. Bai, D. Xu, H. R. Wang, S. Zheng, and H. M. Zhou, "Evidence for the existence of an unfolding intermediate state for aminoacylase during denaturation in guanidine solutions," Biochimica et Biophysica Acta (BBA) Protein Structure and Molecular Enzymology, vol. 1430, p. 39, 1999. [9] J. H. Bai, S. Zheng, and H. M. Zhou, "Inactivation of creatine kinase is due to the conformational changes of the active sites during thermal denaturation," Biochemistry and molecular biology international, vol. 45, p. 941, 1998. [10] S. Zheng, H. R. Wang, J. Li, D. Xu, and H. M. Zhou, "Kinetics of irreversible inhibition of yeast alcohol dehydrogenase during modification by 4,4'-dithiodipyridine," International journal of biological macromolecules, vol. 20, p. 307, 1997. [11] H. R. Wang, J. H. Bai, S. Zheng, Z. H. Wang, and H. M. Zhou, "Ascertaining the number of essential thiol groups for the folding of creatine kinase," Biochemical and biophysical research communications, vol. 221, p. 174, 1996. Refereed Conference Proceedings [1] S. Zheng and Y. C. Tai, "Dual frequency resonance impedance spectroscopy flow cytometry for blood and tumor cells," in Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS'07), Paris, France, Oct. 7-11, 2007, p.488-490. [2] S. Zheng, J. C.-H. Lin, H. L. Kasdan, and Y. C. Tai, "Fluorescent Labeling, Sensing and Differentiation of Leukocytes from Undiluted Whole Blood Samples," in Proceedings of the 14th International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers '07), Lyon, France, June 10-14, 2007, p.807-810. [3] S. Zheng, M. S. Nandra, C. Y. Shih, W. Li, and Y. C. Tai, "Resonance Induced Impedance Sensing of Human Blood Cells," in Proceedings of the 14th International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers '07), Lyon, France, June 10-14, 2007, p. 1741-1744. [4] S. Zheng, M. S. Nandra, and Y. C. Tai, "Human Blood Cell Sensing with Platinum Black Electroplated Impedance Sensor," in Proceedings of the 2nd Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems (IEEE-NEMS' 07), Bangkok, Thailand, Jan. 16-19, 2007, p.520-523. [5] C. Y. Shih, W. Li, S. Zheng, and Y. C. Tai, "A Resonance-Induced Sensitivity Enhancement Method for Conductivity Sensors," in Proceedings of the 5th IEEE Conference on Sensors, Daegu, Korea, Oct. 22-25, 2006, p.271-274. [6] S. Zheng and Y. C. Tai, "Streamline based design of a MEMS device for continuous blood cell separation," in Proceedings of the twelfth in the series of Hilton Head Workshops on the science and technology of solid-state sensors, actuators, and microsystems (Hilton Head 2006), Hilton Head Island, SC, USA, June 6-8, 2006, p. 140-143. [7] S. Zheng and Y. C. Tai, "Design and fabrication of a micro Coulter counter with thin film electrodes," in Proceedings of the 4th Annual International IEEE EMBS Special Topic Conference on Microtechnologies in Medicine and Biology (IEEE-EMBS/MMB2005), Bankoku-Shinryokan, Okinawa, JAPAN, May 5-9, 2006, p. 16-19. [8] S. Zheng, M. Liu, H. L. Kasdan, and Y. C. Tai, "Platinum Black Electroplated Impedance Particle Sensor," in Proceedings of the First Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems (IEEE-NEMS’06), Zhuhai, China, Jan. 18-21, 2006, p.87-91. [9] S. Zheng, Y. C. Tai, and H. L. Kasdan, "MEMS device for continuous blood cell separation," in Proceedings of the 9th International Conference on Miniaturized Systems in Chemistry and Life Sciences (microTAS05), Boston, USA, Oct. 9-13, 2005, p. 385-387. [10] S. Zheng, Y. C. Tai, H. Lin, M. Balic, R. Datar, and R. J. Cote, "Circulating tumor cell capture from whole blood by parylene filter devices," in Proceedings of the 9th International Conference on Miniaturized Systems in Chemistry and Life Sciences (microTAS'05), Boston, USA, Oct. 9-13, 2005, p. 874-876. [11] S. Zheng, Y. C. Tai, and H. L. Kasdan, "A micro device for separation of erythrocytes and leukocytes in human blood," in Proceedings of the 27th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE EMBS'05), Shanghai, China, Sept. 1-4, 2005, p. 1024-1027. [12] S. Zheng, R. Yung, Y. C. Tai, and H. L. Kasdan, "Deterninistic lateral displacement MEMS device for continuous blood cell separation," in Proceedings of the 18th IEEE International Conference on Micro Electro Mechanical Systems (MEMS '05), p. 851-854, Miami Beach, USA, Jan.30-Feb.3, 2005, p. 851-854. [13] C. Y. Shih, S. Zheng, Y. C. Tai, Y. Liu, and J. F. Stoddart, "Shear Flow Self-Assembled Nanoparticle Film For Chemiresistor Applications," in Proceedings of the 8th International Conference on Miniaturized Systems in Chemistry and Life Sciences (microTAS'04), Malmo, Sweden, Sept. 26-30, 2004, p. 339-341. [14] C. Y. Shih, S. Zheng, E. Meng, Y. C. Tai, Y. Liu, and J. F. Stoddart, "Nano-to-Micro Self-Assembly Using Shear-Flow Devices," in Proceedings of the 17th IEEE International Conference on Micro Electro Mechanical Systems (MEMS '04), Maastricht, Netherlands, Jan. 25-29, 2004, p.422-425. [15] C. Y. Shih, S. Zheng, A. Chang, and Y. C. Tai, "Nanometer Gaps by Feedback-controlled Electromigration," in Proceedings of the 12th International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers '03), Boston, USA, Sept. 5-9, 2003, p. 1530-1533. [16] H. Che, S. Zheng, and X. Hong, "A framework for performance analysis of pricing and link bandwidth allocation in a multiple class-of-service Internet," in 9th International Conference on Computer Communications and Networks (IC3N'2000), Las Vegas, USA, Oct. 16-18, 2000. PATENTS[1] Y. C. Tai, S. Zheng, J. C.-H. Lin, and H. Kasdan, "Fluorescent labeling, sensing and differentiation of leukocytes from undiluted whole blood samples", US provisional patent, 2007. [2] Y.-C. Tai and S. Zheng, "Streamline-based microfluidic device", US patent, 2007. [3] Y.-C. Tai, C.-Y. Shih, W. Li, and S. Zheng, "Resonance-Induced sensitivity enhancement method for conductivity sensors", US Patent application 20070247173, 2007. [4] Y. C. Tai, S. Zheng, H. Lin, R. Datar, and R. J. Cote, "Uses of parylene membrane filters", US patent application 20070025883, 2007. [5] Y. C. Tai, S. Zheng, H. Lin, R. Datar, and R. J. Cote, "Membrane filter for capturing circulating tumor cells", US patent application 20060254972, 2006. [6] Y. C. Tai, S. Miserendino, Q. He, and S. Zheng, "Modular microfluidic packaging system", US patent application 20060078475, 2006. [7] Y. C. Tai, C. Y. Shih, and S. Zheng, "Method and system for processing nanoparticles using a self assembly mechanism to form combined species ", US patent application 20060057597, 2006. AWARDS AND HONORSBest Paper Final List, 2nd IEEE NEMS Conference 2007 Atwood Fellowship, California Institute of Technology 2002 Pela Fay Braucher Scholarship, Penn State University 1997 PROFESSIONAL ACTIVITIESConference Presentations and Invited Talks [1] "Blood count on-chip", BMES annual meeting, Los Angeles, CA, September 2007. [2] "Integrated microdevice to capture and detect circulating tumor cells", NCI IMAT meeting, Redwood City, CA, July 2007. [3] "On-chip blood count", Caltech NESS meeting, Pasadena, CA, March 2007. [4] "Development of single-station filter based capture and characterization of circulating tumor cells from peripheral blood", AACR annual meeting, Los Angeles, CA, April 2007. [5] "MEMS Membrane Filter for Capture and Electrical Lysis of Human Circulating Tumor Cells",Micro Scale Separation (MSB 2007), Vancouver, Canada, January 2007. [6] "Handheld body-fluid analysis system for astronaut health monitoring," NASA NSBRI meeting, Houston, TX, February, 2006. [7] "Linear motor-molecule biomimetic muscle," DARPA DSO BioMotor meeting, San Francisco, August 2003. Society Member IEEE, IEEE-EMBS, BMES, ASME, Sigma-Xi
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