email: junxie@mems.caltech.edu

Research and Project

Research Fields:  Microfluidics, MEMS, MicroTotalAnalysisSystem.

Integrated Microfluidic System for LC-ESI

The main goal of the project is to develop an on-chip LC-ESI system coupled with Mass Spectrometry for protein/peptide analysis.  Several polymer micromachining technologies have been combined together to achieve a total integration of the system. A novel electrochemical based actuation method is implemented to realize on-chip high-pressure pumping for gradient elution in LC.

Total Integration of Microfluidic Systems

A multilayer Parylene surface micromachining technology has been successfully developed. The technology involves more than 10 layers of various materials.   Its complexity and diversity match Sandia national lab’s state of the art SUMMIT^TM 5-layer poly-silicon technology.  Various microfluidic devices based on the aforementioned technology have been successfully designed, fabricated and tested. 

Education

Ph.D.     Electrical Engineering,                         Expected Spring 2004
California Institute of Technology,  Pasadena,  CA
Thesis Title: Integrated Microfluidic System for LC-ESI    Advisor: Prof. Yu-Chong Tai

M.S.      Electrical Engineering,                         June 2000
California Institute of Technology,  Pasadena,  CA

B.Eng. Biomedical Engineering,                      June 1996
Zhejiang University,  Hangzhou,  P.R.China

Selected Publications

• Jun Xie, Yunan Miao, Jason Shih, Qing He, Jun Liu, Yu-Chong Tai, and Terry D. Lee, “An Electrochemical Pumping System for On-Chip Gradient Generation”, Analytical Chemistry (Submitted)

• Jun Xie, Jason Shih, Qing He, Changlin Pang, Yu-Chong Tai, Yunan Miao, and Terry D. Lee,  “An Integrated LC-ESI Chip With Electrochemical-Based Gradient Generation”, The 17^th IEEE International Conference on MicroElectroMechanical Systems (MEMS 2004), Maastricht, The Netherlands, January, 2004     (Accepted)

• Jun Xie, Jason Shih and Yu-Chong Tai, “Integrated Parylene Electrostatic Peristaltic Pump”, The Seventh International Symposium on Micro Total Analysis System (mTAS 2003), Squaw Valley, California, USA, October, 2003, pp.865-868

• S. Matsumoto, Jun Xie and Yu-Chong Tai, “Polymer Micro Interface for Fluidic Probing”, The Seventh International Symposium on Micro Total Analysis System (mTAS 2003), Squaw Valley, California, USA, October, 2003, pp.551-554

• Jun Xie, Jason Shih and Yu-Chong Tai, “Integrated Surface Micromachined Mass Flow Controller”, The 16^th IEEE International Conference on MicroElectroMechanical Systems (MEMS 2003), Kyoto, Japan, January, 2003, pp.20-23

• Jun Xie, Qing He, Yu-Chong Tai, Jun Liu and Terry Lee, “Electrolysis-Based On-Chip Dispensing Sysmtem for ESI-MS”, The 16^th IEEE International Conference on MicroElectroMechanical Systems (MEMS 2003), Kyoto, Japan, January, 2003, pp.443-446

• Jason Shih, Jun Xie, Yu-Chong Tai, “Surface Micromachined and Integrated Capacitive Sensors For Microfluidic Applications”, The 12^th International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers 2003), Boston, USA, June, 2003, pp.388-391

• Jun Xie, Qing He, Yu-Chong Tai, Jun Liu and Terry Lee, “Integrated Electrospray Chip for Mass Spectrometry”, The Sixth International Symposium on Micro Total Analysis System (mTAS 2002), Nara, Japan, November, 2002, pp.709-711

• Liu Jun, Jun Xie, Qing He, Yu-Chong Tai, and Terry Lee, “Microfluidic Components for Chip-based Sample Preparation Systems”, The 50^th ASMS Annual Conference on Mass Spectrometry and Allied Topics, Orlando, Florida, June 2002

• Jun Xie, Xing Yang, Xuan-Qi Wang, and Yu-Chong Tai, “Surface Micromachined Leakage Proof Parylene Check Valve”, Technical Digest of the 14^th IEEE International Conference on MicroElectroMechanical Systems (MEMS 2001), Interlaken, Switzerland, January, 2001, pp.539-542

• Ping Wang and Jun Xie, “A novel recognition method for electronic nose using artificial neural network and fuzzy recognition”, Sensors and Acuators B: Chemical, Vol.37, No.3, December 1996, pp.169-174