|
|
Changlin Pang |
|
|
|
|
|
|
|
|
|
|
136-93
Caltech E-mail: pang@mems.caltech.edu |
|
|
|
Ph.D. Electrical Engineering, California Institute of
Technology ... M.S. Electrical Engineering, California Institute of Technology (Sept 2002 - June 2003) M.S. Precision Instruments and
Mechanology, Tsinghua University, B.S. Precision Instruments and
Mechanology, Tsinghua University, Research High Density Silicon Probes with
Flexible Cables for Neural Prostheses (2003-present) An
important common goal, although futuristic, is to achieve cortex prostheses
using implanted probes to control robotics by pure thoughts. The first
beneficiaries are likely to be patients with spinal-cord injuries, peripheral
nerve disease, or amyotrophic lateral sclerosis. We are developing a
new parylene-enabled silicon neural probe electrode sensor for a neural
prostheses direct brain interface system. We successfully combined parylene
coating/etching process with silicon neural probes dry etching process to
build parylene on silicon probes as insulating and protecting material, and
at the same time to monolithically integrate flexible parylene cables with
silicon neural probes. The new neural probes were shown to have better
biocompatibility, lower stress, and better flexibility to be made to
high-density 3-Dimensional array and to be used for chronic neural signal
recording implantation. Right now, we are aiming for high density probe array
with one hundred electrode sensors for clinical trials.
MEMS Movable Neural Probes
(2003-present) Recent studies using
neural probes indicate that it is highly desirable for the probes to have
moving capability so that it can track a specific neuron in the brain,
because live neurons do move around. However, for brain use, the movable
neural probes need to be powerful (to penetrate brain tissue), high density,
low power, bidirectional and latchable (without power). We are now developing
a novel electrolysis-based parylene balloon actuator for movable probes. Ion-Chromatography On-a-Chip for
Water Analysis (2002-2003) Publications Conference Papers [1] C. Pang, Y.-C. Tai, J. W. Burdick,
and R. A. Andersen, "Electrolysis-based Parylene Balloon Actuators for
Movable Neural Probes," presented at The Second Annual IEEE
International Conference on Nano/Micro Engineered
and Molecular Systems (IEEE-NEMS'07), [2] C. Pang, S. Musallam,
D. Rizzuto, C. Ustun,
Y.-C. Tai, J. W. Burdick, and R. A. Andersen, "Vivo Study of Mechanical
Properties for the Monolithic Silicon Probes with Flexible Parylene Cables
for Neural Prostheses," presented at The 10th International Conference
on Miniaturized Systems for Chemistry and Life Sciences (µTAS’06), Tokyo,
Japan, Nov. 5-9, 2006. [3] D.S. Rizzuto, S. Musallam, C. Pang, R. Huang, Y.-C. Tai, and
R.A. Andersen, "The Caltech Brain-Machine Interface Platform,"
presented at The 36th Annual Meeting of Society for Neuroscience
(Neuroscience2006), Atlanta, Georgia, Oct 14-18, 2006 [4] C. Ustun, S. Musallam, M. J. Bak, P. R. Troyk, C. Pang, Y.-C. Tai, R. A. Andersen,
"Floating microelectrode arrays for chronic implantation,"
presented at The 36th Annual Meeting of Society for Neuroscience
(Neuroscience2006), Atlanta, Georgia, Oct 14-18, 2006 [5] C. Pang, S. Musallam,
Y.-C. Tai, J. W. Burdick, and R. A. Andersen, "Novel Monolithic Silicon
Probes with Flexible Parylene Cables for Neural Prostheses," presented
at The 4th International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology (MMB’06),
Okinawa, Japan, May 9-12, 2006. [6] C. Pang, J. G.Cham,
S. Musallam, Y.-C. Tai, J. W. Burdick, and R. A.
Andersen, "Monolithic Silicon Probes with Flexible Parylene Cables for
Neural Prostheses," presented at The First Annual IEEE International
Conference on Nano/Micro Engineered and Molecular
Systems (IEEE-NEMS'06), Zhuhai, China, Jan. 18-21, 2006. [7] C. Pang, J. G.Cham,
Z. Nenadic, Y.-C. Tai, J. W. Burdick, and R. A.
Andersen, "A New Neural Recording Electrode Array with Parylene
Insulating Layer," presented at The Ninth International Conference on
Miniaturized Systems for Chemistry and Life Sciences (µTAS’05), Boston,
Massachusetts, USA, Oct. 9-13, 2005. [8] C. Pang, J. G.Cham,
Z. Nenadic, S. Musallam,
Y.-C. Tai, J. W. Burdick, and R. A. Andersen, "A New Multiple-Site Probe
Array with Monolithically Integrated Parylene Flexible Cable for a Neural
Prosthesis," presented at The 27th Annual International Conference of
the IEEE Engineering in Medicine and Biology Society (EMBC 2005), Shanghai,
China, Sept. 1-4, 2005. [9] C. Pang, Y.-C. Tai, J. W. Burdick,
and R. A. Andersen, "Electrolysis-Based Diaphragm Actuators,"
presented at The International Conference on Bio-Nano-Informatics
(BNI) Fusion, Marina del Rey, California, USA, July
20-22, 2005. [10] Q. He, C. Pang, Y.-C. Tai, and T. D. Lee,
"Ion Liquid Chromatography On-a-Chip with Beads-Packed Parylene
Column," presented at The 17th IEEE International Conference on MicroElectroMechanical Systems (MEMS 2004), Maastricht,
the Netherlands, Jan. 25-29, 2004. [12] J. Xie, J. Shih, Q. He, C.
Pang, Y.-C. Tai, Y. Miao, and T. D. Lee, "An Integrated LC-ESI Chip
With Electrochemical-Based Gradient Generation," presented at The 17th
IEEE International Conference on MicroElectroMechanical
Systems (MEMS 2004), Maastricht, the Netherlands, Jan.
25-29, 2004. [13] C. Pang, X. Wang, and Z. Zhou,
"A Miniaturized Bioreactor for Cell Cultivation in Space,"
presented at The 2nd International Symposium on Instrumentation Science and
Technology, Jinan, China, Aug. 18-22, 2002. Journal Papers [1] C. Pang, Y.-C. Tai, J. W. Burdick,
and R. A. Andersen, “Electrolysis-based Diaphragm Actuators,” NANOTECHNOLOGY,
17 (2006) S64-S68. [2] C. Pang, X. Wang, Z. Zhou, and G. Ku,
"Parameter Identification of Micro Semiconductor Cooling System Based on
Semiconductor Cooler," Chinese Journal of Scientific Instrument, vol.
24, pp. 605-607, 2003. [3] C. Pang, X. Wang, Z. Zhou, G. Ku, and
J. Lu, "Experiment Study for Micro Constant Temperature Controlling
System Based on Semiconductor Cooler," Instrument Technique and Sensor,
vol. 2, pp. 12-14, 2002. Patents [1] Y.-C. Tai,
Q. He, J. Xie, C.
Pang, and T. D. Lee, "Design of an IC-Processed Polymer Nano-Liquid Chromatography System On-a-Chip and Method of
Making It," 2003. Awards Caltech Engineering Division
Fellowship (2002-2003) Undergraduate and graduate PrizeⅠfellowship in Tsinghua University every year: Dong Shi Dong Fang Fellowship
(2000-2001) Jiang Nanxiang
Fellowship (1998-1999) Motorola Fellowship (1997-1998) Holison Fellowship
(1996-1997) Tsinghua University Honored
Graduate Student (2000) |
|
|
|
|